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Research in pathogenesis and applied genomics |
New
awards
July 2005 |
The TDR Committee on Pathogenesis and Applied Genomics (PAG) [workplan] met in
Geneva, Switzerland, to deliberate and recommend projects for funding by TDR. The projects listed below were selected from among a large number of applications received from investigators worldwide including projects submitted to the committee on Vaccines Discovery Research (VDR). The VDR is currently being revaluated and its meeting has been postponed indefinitely.
New
grants in pathogenesis and applied genomics
These grants will be funded for 12 months in the first instance, and for an additional 1 year if sufficient progress is made in the first 12 months toward reaching the scientific objectives, and if sufficient funds are available.
Project
ID |
Principal Investigator |
Institution |
|
Project Title |
Funding in US$ |
| A50227 |
Liwang
Cui |
Pennsylvania State University, University Park, USA |
|
The proteome of the malaria
Plasmodium vivax |
27,000 |
| A50524 |
Stewart
Cole |
Institut Pasteur, Paris, France |
|
Towards an immunodiagnostic kit for leprosy |
70,500* |
| A50312 |
Walderez
Dutra |
Universidade Federal de Minas Gerais, Belo Horizonte, Brazil |
|
Mechanistic analysis of the role of CD28+and CD28-cells in human Chagas disease: towards the understanding of pathology |
35,000 |
| A50209 |
Lashitew
Gedamu |
University of Calgary, Calgary, Canada |
|
Cathepsin B from
Leishmania donovani complex: role in the pathogenesis of leishmaniasis |
35,000 |
| A50263 |
Hema
Joshi |
Malaria Research Center, Indian Council of Medical Research, New Delhi, India |
|
Evolutionary history of human malaria parasite
Plasmodium falciparum in India: population genomic approach |
35,000 |
| A40222 |
Johanna
Kelley |
University of Maryland, Baltimore, USA |
|
Efficacy of a pre-erythrocytic vaccine: irradiated sporozoites developed in vitro in
P. yoelii malaria mouse model |
5,000 |
| A50240 |
Yuesheng
Li |
Queensland Institute of Medical Research, Brisbane, Australia |
|
Human immune-effector mechanisms in the pathophysiology of schistosome-induced hepatic fibrosis and advanced disease |
35,000 |
| A50354 |
Daniel
Masiga |
Kenyatta University, Department of Biochemistry, Nairobi, Kenya |
|
The development and improved production of a diagnostic for Human African Trypanosomiasis |
30,000 |
| A50230 |
Anuja
Mathew |
University of Massachusetts Medical School, Boston, USA |
|
Humanized SCID mice for dengue infection and immunity |
35,000 |
| A50367 |
Enock
Matovu |
Makerere University, Kampala, Uganda |
|
The immunogenic/diagnostic potentials of cysteine proteinase and nucleoside transporters of Trypanosoma brucei |
30,000 |
| A50304 |
Leila
Mendonca-Lima |
Fundacao Oswaldo Cruz Bioquimica e Biología Molécula, Rio de Janeiro, Brazil |
|
Mycobacterium bovis BCG moreau RJ: functional genomic studies applied to the improvement of vaccine production |
30,000 |
| A50252 |
Laura Ines
Rutitzky |
Tufts University, Department of Pathology, Boston, USA |
|
Glycan residues on the Sm-p40 schistosome egg antigen: characterization and role in T cell response |
35,000 |
*Joint project between PAG and diagnostics initiative in TDR
New
South-South collaboration grants in pathogenesis and applied genomics
These multicenter grants will be funded for one year in the first instance, and for an additional year if sufficient progress is made in the first year toward reaching the scientific objectives, and if sufficient funds are available. A two week training workshop on the use of non-human primate models for research in tropical diseases will be funded as a joint effort with other agencies in order to enhance applications of the models in research and development of new interventions.
Project
ID |
Principal Investigator |
Institution |
|
Project Title |
Funding in US$ |
| A50337 |
Christian
Happi |
University of Ibadan, College of Medicine, Ibadan, Nigeria |
|
Molecular determinants of drug response and resistance in
P. falciparum from Africa and South-America |
45,000 |
| A50271 |
Mariano Jorge
Levin |
Instituto de Investigaciones en Ingenieria Genetica y Biologia, Buenos Aires, Argentina |
|
Specific molecular mechanisms as target of novel anti-parasitc drugs |
55,000 |
| A50205 |
Michael Muita
Gicheru |
Institute of Primate Research, Nairobi, Kenya |
|
A two week training workshop on the use of non-human primate models for research in tropical diseases |
30,000 |
Renewed
grants in pathogenesis and applied genomics
These projects were funded for the initial 12 months either in 2002, 2003 or 2004, by the committees on Pathogenesis and Applied Genomics or the committee on Vaccines Discovery Research. The projects funded in 2003 were provided interim award for six months in December 2004 in order to avoid hiatus in activities on the projects and because of the change in dates of the committee meeting. Each of the projects are now being renewed for either a further six months (those funded in 2003) or a further year following the successful progress made towards meeting the objectives during the first year.
Project
ID |
Principal Investigator |
Institution |
|
Project Title |
Funding in US$ |
| A40098 |
Maria Isabel
Cano |
Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil |
|
Functional & biochemical characterization of the putative
Leishmania telomeric proteins LaRpa-1 and LaRbp38 |
20,000 |
| A30406 |
Mariangela
Carneiro |
Universidade Federal de Minas Gerais, Belo Horizonte, Brazil |
|
Longitudinal study of asymptomatic
Leishmania chagasi infection in urbanarea of Mina Gerais State, Brazil |
3,500 |
| A30378 |
Sungae
Cho |
Yonsei University Medical Center, Seoul, Korea |
|
Identification of HLA-A 0201 restricted CD8+T cell specific peptide epitopes encoded from whole
M. tuberculosis genome |
25,000 |
| A30306 |
Christian
Engwerda |
Queensland Institute of Medical Research, Herston, Australia |
|
Defining the role of NK T cells in murine visceral leishmaniasis |
17,500 |
| A30407 |
John Charles Kiboko
Enyaru |
Livestock Health Research Institute (LHRI), Tororo, Uganda |
|
Evaluation of the epidemological significance of an animal reservoir in Gambiense sleeping sickness in N. W. Uganda |
5,000 |
| A30288 |
Idle Omar
Farah |
National Museums of Kenya Institute of Primate Reserch, Nairobi, Kenya |
|
Prenatal exposure to schistosomiasis in the baboon: the immunopathologic impact on the foetus |
15,780 |
| A20352 |
Ana Maria
Faria |
Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Brazil |
|
Aging and immunoregulation in chronic human schistosomiasis |
15,000 |
| A30408 |
Giovanni Gazzinelli |
Centro de Pesquisas Rene Rachou - Fiocruz, Belo Horizonte, Brazil |
|
Role of S.
mansoni-derived antigens in the regulation of cell cycle progression and lymphoproliferation |
22,500 |
| A40101 |
Ricardo Tostes
Gazzinelli |
Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Brazil |
|
Role of Toll-like receptors in malaria pathogenesis |
35,000 |
| A40089 |
Emmanuela
Handman |
Walter and Eliza Hall Institute of Medical Research, Parkville, Australia |
|
A new model to study the role of innate immunity in the pathophysiology of
Leishmania major infection |
35,000 |
| A30358 |
Sumalee
Kamchonwong-
paisan |
National Center for Genetic Engineering and Biotechnology, Bangkok, Thailand |
|
Integrated genomic & proteomic studies for identification of potential targets of artemisinin and derivatives |
12,500 |
| A40234 |
Mohamed Hechmi
Louzir |
Institut Pasteur de Tunis, Tunisia |
|
Host-parasite relationships: induction of regulatory immune mechanisms as expression of wild
Leishmania major virulence |
28,000 |
| A20198 |
Weiqing
Pan |
Second Military Medical
Univ., Institute of Medic. Biotechnol. & Molecular Genetics, Department of Parasitology, Shanghai, China |
|
Construction & immunogenicity of combined malaria vaccine containing PfCP-2.9 & pre-erythrocytic stage antigens |
35,000 |
| A40263 |
Carlos
Andre Ricart |
Universidade de Brasília, Departmento de Biologia Celular, Brasilia, Brazil |
|
Trypanosoma cruzi proteomics initiative |
34,000 |
| A30322 |
Ya Ping
Shi |
Kenya Medical Research Institute, Kisumu, Kenya |
|
Genetic polymorphism of IL-12 p40 subunit and MIF in severe malaria anemia in children residing in western Kenya |
17,500 |
| A40092 |
Worachart
Sirawaraporn |
Mahidol University Department of Biochemistry, Bangkok, Thailand |
|
Exploring the non-active site region of
Plasmodium falciparum DHFR-TS as molecular target for inhibitor design |
35,000 |
| A30325 |
Luc Jean
Vanhamme |
Universite Libre de Bruxelles - IBMM - Lab. de Parasitologie Moleculaire, Brussels, Belgium |
|
Charact. of trypanolytic activity of human apolipoprotein L1 & its neutralization by
Trypanos. rhodesiense & gambiense |
15,000 |
| A30313 |
Robert Alan
Wilson |
University of York, Department of Biology, York, UK |
|
The architecture of the schistosome tegument: putting known and novel proteins into a structural and functional context |
15,000 |
| A20095 |
Zhou
Xing |
McMaster University, Department of Pathology and Molecular Medicine, Hamilton, Canada |
|
Development of recombinant adenoviral tuberculosis vaccines |
30,000 |
| A30375 |
Dan Zilberstein |
Technion-Israel Institute of Technology, Haifa, Israel |
|
Proteomic analyses of
Leishmania donovani differentiation |
16,575 |
Renewed grants in South-South collaboration in
pathogenesis and applied genomics
This project was funded in 2003, provided an interim award for six months in December 2004 in order to avoid hiatus in activities on the project and because of the change in dates of the committee meeting. It is now being renewed for a further six months following the successful progress made towards meeting the objectives during the first year.
Project
ID |
Principal Investigator |
Institution |
|
Project Title |
Funding in US$ |
| A30380 |
Ikram
Guizani |
Institut Pasteur de Tunis, Tunisia |
|
Post Kala-Azar dermal leishmaniasis (PKDL): molecular epidemiology and prognostic markers |
30,130 |
TDR expresses sincere gratitude to
members of the Steering Committees and to external reviewers for their
critical assessment and contributions to the selection process.
TDR would also like to thank those
investigators who were not funded. A large number of projects were
reviewed but only a few selected due to the highly competitive selection
process. TDR wishes to encourage these investigators to continue their
good work and to re-compete next year (see deadline
for submission of new applications).
Detailed information on funding and how
to apply for support from the Committee on Pathogenesis and Applied
Genomics (PAG and the South-South Initiative can be obtained from the
following web site http://www.who.int/tdr/grants, http://ssi-tdr.net and from Dr Ayoade M. J. Oduola, Manager
Pathogenesis and Applied Genomics Committee
TDR contact: Dr A Oduola
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