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October 2004

RCS workplans

WORKPLAN  of  RESEARCH CAPABILITY STRENGTHENING (RCS) (full text)

BACKGROUND

The mission of the TDR Research Capability Strengthening (RCS) is to foster self-reliance in biomedical and social science research in disease-endemic developing countries (DECs) by building a critical mass of human resources, institution capacity, and a conducive environment able to respond to public health research needs. RCS is thus a cross-cutting programmatic area of TDR, established to promote and fund research training and institution development, and to increase the participation of developing countries in the development and use of new tools for the diagnosis, treatment, prevention and control of communicable diseases. Examples of TDR's investment in health and development can be seen in the publication Research capacity building in developing countries: investing in health and development (document TDR/RCS/GEN/03.1). 

RCS activities aim to contribute to the definition of research priorities, conduct of research, and translation of results into evidence-based health policy. This can be ensured by increasing access to, and use of, new scientific knowledge by DECs through modern information and communication technologies. The core of the RCS strategy is to create partnerships, increase networking, and promote equal opportunities, ensuring a gender and geographically balanced generation of scientists.

In the TDR RCS Strategy 2002-2005 (document TDR/RCS/SP/02.1), research capability strengthening activities have been refocused along three lines of support within two major strategic directions, each with clearly distinguished budget targets, processes and procedures: a) researcher-driven capacity building, and b) R&D-driven capacity building. 

Lines of support are for:

  • Long-term RCS institutional programmes restricted to least developed, high disease burden, low income countries within a broad strategic research agenda. Such support accounts for 40% of the resources available. The objective is to further reduce the scientific and health condition gap confronted by the countries in most need.
  • Targeted research and development (R&D)-driven initiatives ('RCS Plus') proposed as priorities by the different steering committees and jointly managed by RCS and the other TDR units. These are open to all disease endemic developing countries. Sixty per cent of the resources will be dedicated to these initiatives.
  • Individual capacity building aimed at supporting individuals to gain R&D skills and competencies and to develop independent research careers. This includes Research Training Grants, Re-entry grants, Career Development Fellowships. 

MODUS OPERANDI 

The RCS workplan and research proposals are reviewed annually, and funding approved, by the Research Strengthening Group (RSG). The strategic plan is reviewed annually by TDR's Scientific and Technical Advisory Committee (STAC). 

Capacity strengthening programme grants support long-term institutional and research group development in least developed countries and countries with low research capacity. The grants are expected to assist in developing research leadership, promoting the development of infrastructure and the research environment, improving training opportunities, and increasing scientific expertise in biomedical and social sciences areas. The grants also include support for information and communication systems, as well as Internet connectivity. Opportunities for collaboration with scientists and institutions in advanced developing and industrialized countries will be encouraged. Proposals will be developed with TDR's assistance and will be reviewed on the basis of soundness of the scientific development plan and vision, relevance of the research, and explicitness of the expected outcomes. Financial support will be for an initial period of one to three years (subject to annual review and satisfactory progress). 

Research and development (R&D)-driven capability strengthening grants (RCS-Plus) will support projects and activities announced through specific calls for applications as part of joint initiatives developed across TDR teams and respective steering committees. The initiatives will be introduced through recommendation by TDR's R&D areas and steering committees, and will be guided by TDR's comparative advantages and disease strategic emphases. An initiative team formed by TDR staff and external experts will be responsible for managing individual initiatives. Priority will be given to specific areas with the greatest potential impact on disease control and RCS outcomes. It is envisaged that the programme will address priority issues from laboratory-based research, through field intervention research, to social-economic behavioural research. 

Research training grants (RTGs) are awarded on a competitive basis to nationals from least developed countries (and countries with lesser developed research capacities) working in a developing country institution. RTGs aim to support higher degree training (locally or regionally) or short-term postdoctoral fellowships in the biomedical or social sciences on TDR target diseases. Applications for training must be designed as an integral part of an institution development programme rather than an individual request. Applicants must indicate how the proposed training will strengthen the research capabilities of the home institution and/or how it will assist in the planning and evaluation of a particular disease control programme. Further, the institute director must also identify the career development opportunities for the applicant upon return from training. All applicants must have fixed employment. 

Re-entry grants are awarded on a competitive basis to scientists from developing countries returning to their home institution after completing a minimum period of 12 months research training within the past 12 months. Priority is given to recent master's and doctoral graduates, as well as those completing post-doctoral studies. The awards aim to enable young scientist's to establish their research career, develop a career path, and continue collaborating with their training institution. All applicants must describe how this grant will facilitate these three aims. In addition, the director of the home institute must describe the career path of the scientist; the previous academic supervisor(s) must provide letters of recommendation; and, as appropriate, all potential collaborators must provide letters of support. The grants are awarded for a 3-year period for a maximum of US$ 40 000 over the 3-year period of the grant. 

FOCUSED RCS ACTIVITIES

  • Current RCS-Plus initiatives include: 4-drug fixed-dose combinations (4FDCs) for tuberculosis; optimization of praziquantel treatment for schistosomiasis; preparation of vaccine trials for leishmansiasis; natural products for treatment of malaria; bioinformatics training centres for functional genomics; socioeconomic determinants of multidrug resistant tuberculosis.
  • Small grants programmes are designed to provide support to operations research and to research theses on subjects relevant to disease control. Programmes are run by the Pan American Health Organization (PAHO), the WHO Eastern Mediterranean Regional Office (EMRO), and the WHO South-East Asia Regional Office (SEARO). Calls for applications are issued annually.
  • Partnerships and networks. RCS continues its strategy of developing and maintaining partnerships with other groups and organizations sharing similar or complimentary goals. These include the Regional Network for Asian Schistosomiasis (RNAS), International Network of Field Sites with Continuous Demographic Evaluation of Populations and their Health in developing countries (INDEPTH), Partnership for Social Science for Malaria Control (PSSMC), and the International Clinical Epidemiology Network (INCLEN).
  • TDR Career Development Fellowships (CDFs) provide specialized training opportunities in areas of high priority to TDR. The fellowships are generally awarded jointly in collaboration with another organization. They include TDR-EMRO CDF grants management; TDR-SEARO CDF grants management; TDR(MIM)-WHO/AFRO CDF small grants malaria; TDR-HINARI CDF E-information management; TDR-Wellcome Trust CDF interactive learning production; TDR-International Disease Research Institute CDF vaccine trial management; TDR-Pasteur CDF basic science.
  • Good practices for product development. Group training and guideline development on principles of good laboratory practices (GLP), good clinical practices (GCP) and good manufacturing practices (GMP) are conducted annually for investigators involved in product research and development. · Strengthening ethical review activities are geared to promoting and strengthening institutional review boards in DECs and to developing guidelines for ethical review of research proposals.
  • Internet connectivity. TDR actively promotes the WHO Health InterNetwork (HINARI) initiative to improve global public health by facilitating the flow of health information worldwide, using the Internet, to enable more effective research and health service delivery through access to high quality, relevant and timely information. In addition, TDR provides training and infrastructure support.
  • Strengthening communicable diseases journals in developing countries. RCS initiated the Forum of African Medical Editors (FAME) to strengthen local publication of health research conducted in, or relevant to, Africa in order to give greater visibility to African medical research. The secretariat is located in KEMRI, Nairobi, Kenya, and is a partnership with the publishers of international health and medical journals. 

A strategic emphasis matrix for RCS activities by TDR and expected results are described in RCS Strategy 2002-2005. Briefly, in least developed, high burden, low income countries, TDR will focus on developing a critical mass of investigators, increasing training in basic disciplines, and opening opportunities in preclinical and clinical development through within-project training and support to disease control-related projects. Implementation research and health systems and policy research are important approaches to developing research leadership and to introducing research culture into the health system. For some advanced developing endemic countries, emphasis will be placed on using the research capacity available in them for networking, carrying out multicentre studies, research partnerships within R&D driven-projects in basic research, product development, and applied field research. 

HOW TO APPLY

Researchers interested in collaborating in the above activities should respond to the respective call for applications when posted on the website. When necessary, additional information and/or application forms can be requested from the Research Capability Strengthening secretariat:

Dr Fabio Zicker, Coordinator
Research Capacity Strengthening
WHO/TDR
20 Avenue Appia
WHO/TDR
1211 Geneva 27
Switzerland

Tel: (41 22) 791 3805
Fax: (41-22) 791 4854
Email: rcstdr@who.int

RCS workplans

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