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SDR
Workplans
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Rationale
The development of new therapeutics for important parasitic diseases of humans is essential for the control of these pathogens. Such efforts rely on screening potentially effective compounds in pathogen growth/multiplication assays, both
in vitro and in vivo. However, in the case of the parasites that cause malaria and leishmaniasis, these assays have technical limitations that potentially restrict drug development, so the ability to derive transgenic parasites expressing proteins such as green fluorescent protein (GFP) and luciferase has opened up new possibilities for high throughput drug screening.
This workplan is designed to develop a network of investigators who will bring overlapping expertise to the development and assessment of transgenic parasites and to their use in models for the development of antiparasitic drugs. The network will provide a broad array of expertise to ensure timely development of tools and assessment of their utility for drug screening and technology sharing. Additionally, there will be a strong component of training to allow transfer of technology between the network partners.
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